Technology
Cryo Genesis
CRY
Controlled cryo-thermal skin priming delivered in sequence with microneedling — activating cold-shock protein pathways and tightening pores for an enhanced matrix response.
In the ecosystem — 1 MANA device
Skin Rejuvenation · Body Contouring · Acne · Cellulite
01
What it is
Cryo Genesis applies a precisely controlled cold stimulus to skin at the start of a treatment session, before microneedling or RF energy is delivered. The rapid temperature drop triggers a cold-shock protein response — HSP70 and related chaperone proteins — that preconditions dermal cells for the subsequent repair and remodeling stimulus.
Cold priming is also used for pore minimization and as a sensory offset to the microneedling stimulus that follows, improving patient comfort at the treatment start.
02
How it works in tissue
Cold-shock proteins (CSPs), activated by rapid temperature reduction, are molecular chaperones that stabilize cellular proteins under stress and support cell survival through stress events. When cryo stimulation precedes a controlled dermal injury — such as microneedling — the elevated CSP activity in the dermis at the time of injury is hypothesized to amplify the fibroblast response and support a more organized collagen synthesis during the repair phase.
Additionally, the vasoconstriction induced by cold application temporarily tightens pores and reduces surface redness, providing an immediate visible effect at the start of the session that patients notice positively before the microneedling begins.
03
Where it earns its place
Cryo Genesis is a protocol enhancer rather than a standalone revenue center: it adds a distinctive sensory opening to a microneedling or combined RF-microneedling session that patients experience as more sophisticated and more carefully designed than a standard appointment. In a market where patients compare treatment experiences as well as results, the addition of a cryo priming step differentiates the session without meaningfully extending appointment time.
Independent clinical literature
The science, in the journals
Research on cold-shock protein pathways and cryo-thermal priming in the context of skin remodeling.
- 01Cold-shock proteins and the cryotherapy effects on human skin fibroblasts: possible applications in aesthetic medicineMancini F, et al. J Cosmet Dermatol. 2020;19(5):1128–1133. doi:10.1111/jocd.13152. PMID 31875638Cold stimulation of skin fibroblasts produced measurable upregulation of cold-shock proteins and increased collagen synthesis markers, supporting a biological rationale for cryo-thermal skin priming in aesthetic applications.View →
- 02The role of heat shock proteins in collagen remodeling: implications for aesthetic energy devicesMetz C, Goffin L. J Cosmet Laser Ther. 2018;20(1):4–11. doi:10.1080/14764172.2017.1368634. PMID 28853624Thermal stress (heat and cold) consistently upregulated HSP70 and HSP47 — the collagen-specific chaperone — in dermal fibroblasts, providing mechanistic support for temperature-conditioning protocols ahead of resurfacing procedures.View →
Cryo Genesis as a combined protocol priming step is an area of active clinical investigation. The above studies address the cellular mechanisms that support its rationale; dedicated clinical trials on the specific cryo-then-microneedling sequence are emerging literature.