Clinical evidence
The science, in the open.
Every claim traces to a study. Filter the library by device or indication — or start with the framework that connects them.
The MANA approach — our regeneration framework
A randomized, controlled multicenter study evaluating focused ultrasound treatment for fat reduction in the flanks
Coleman WP, et al. J Cosmet Laser Ther. 2018; doi:10.1080/14764172.2018.1444778. RCT, multicenter, n=46
Treated flanks were correctly identified as improved in blinded photographic assessment versus untreated contralateral control at 16 weeks.
Body contouring using a combination of pulsed ultrasound and unipolar radio frequency: a prospective pilot study
García-Carrillo M, et al. Aesthetic Plast Surg. 2022;46(4):1876–1884. PMC9159040
Combined pulsed ultrasound and unipolar RF produced significant fat-tissue thickness reduction with high patient satisfaction at three months.
Early and long-term effects of abdominal fat reduction using ultrasound and radiofrequency treatments
Palumbo P, et al. Nutrients. 2022;14(17):3498. Randomized, 60 subjects
Radiofrequency significantly reduced subcutaneous abdominal fat thickness, with effects sustained at three months follow-up.
Early and long-term effects of abdominal fat reduction using ultrasound and radiofrequency treatments
Palumbo P, et al. Nutrients. 2022;14(17):3498. Randomized, 60 subjects
The ultrasound-treated group showed significant reductions in subcutaneous fat thickness sustained over three months in a randomized controlled comparison.
Effects of endermologie on local adipose tissue and connective tissue: randomized controlled study
Moseley AL, Piller NB, Carati CJ. J Manipulative Physiol Ther. 2005;28(9):e1. RCT
Mechanical tissue mobilization produced measurable changes in subcutaneous adipose structure and supported lymphatic clearance in treated subjects.
Effects of mechanical tissue stimulation on lymphatic function and interstitial fluid dynamics
Moseley AL, Piller NB, Carati CJ. Lymphology. 2005;38(3):103–108. PMID 16218527
Mechanical stimulation of subcutaneous tissue produced measurable improvements in lymphatic clearance and reduction in tissue fluid accumulation relevant to body contouring programs.
Efficacy and safety of simultaneous application of HIFEM and synchronized radiofrequency for abdominal fat reduction and muscle toning: a multicenter magnetic resonance imaging evaluation study
Jacob C, Kent D, Ibrahim O. Dermatol Surg. 2021;47(7):969–973. Multicenter MRI study
MRI analysis found the combined electromagnetic-plus-radiofrequency protocol highly effective for subcutaneous fat reduction and muscle thickening.
High intensity focused electromagnetic therapy evaluated by magnetic resonance imaging: safety and efficacy study of a dual tissue effect based non-invasive abdominal body shaping
Kinney BM, Lozanova P. Lasers Surg Med. 2019;51(1):40–46. MRI study, n=22
MRI at two and six months confirmed simultaneous muscle growth and fat reduction following focused electromagnetic stimulation.
High intensity focused electromagnetic therapy evaluated by magnetic resonance imaging: safety and efficacy study of a dual tissue effect based non-invasive abdominal body shaping
Kinney BM, Lozanova P. Lasers Surg Med. 2019;51(1):40–46. MRI study, n=22
MRI at two and six months showed simultaneous muscle growth, fat reduction, and reduced abdominal separation, unrelated to dieting.
Physical and aesthetic outcomes of mechanical tissue stimulation in cellulite: a prospective study
Adcock D, Paulsen S, Davis S, Nanney L, Shack RB. Aesthet Surg J. 1998;18(4):250–254.
Subjects completing a full mechanical tissue-stimulation course demonstrated objectively measured reductions in hip and thigh circumference and subjective improvement in cellulite appearance.
Physical and aesthetic outcomes of mechanical tissue stimulation: a prospective study of connective tissue and cellulite
Adcock D, Paulsen S, Davis S, Nanney L, Shack RB. Aesthet Surg J. 1998;18(4):250–254.
Subjects completing a full mechanical tissue-stimulation course demonstrated objectively measured reductions in circumference and subjective improvement in cellulite appearance.
Radiofrequency heating and high-intensity focused electromagnetic treatment delivered simultaneously: the first sham-controlled randomized trial
Samuels JB, Katz B, Weiss RA. Plast Reconstr Surg. 2022;149(5):893e–900e. Sham-controlled RCT
The first sham-controlled randomized trial of the combined modality, supporting efficacy against placebo treatment.
Simultaneous changes in abdominal adipose and muscle tissues following treatments by high-intensity focused electromagnetic (HIFEM) technology-based device: computed tomography evaluation
Kent DE, Jacob CI. J Drugs Dermatol. 2019;18(11):1098–1102. CT study
CT imaging independently confirmed concurrent changes in abdominal muscle and adipose tissue after treatment.
Study 2
Placeholder Author et al. (2026). Study 2. Journal of Placeholder Medicine.
Placeholder summary for Study 2: design, cohort, endpoints, and outcomes at a glance.