Clinical evidence
The science, in the open.
Every claim traces to a study. Filter the library by device or indication — or start with the framework that connects them.
The MANA approach — our regeneration framework
Efficacy and safety of simultaneous application of HIFEM and synchronized radiofrequency for abdominal fat reduction and muscle toning: a multicenter magnetic resonance imaging evaluation study
Jacob C, Kent D, Ibrahim O. Dermatol Surg. 2021;47(7):969–973. Multicenter MRI study
MRI analysis found the combined electromagnetic-plus-radiofrequency protocol highly effective for subcutaneous fat reduction and muscle thickening.
High intensity focused electromagnetic therapy evaluated by magnetic resonance imaging: safety and efficacy study of a dual tissue effect based non-invasive abdominal body shaping
Kinney BM, Lozanova P. Lasers Surg Med. 2019;51(1):40–46. MRI study, n=22
MRI at two and six months confirmed simultaneous muscle growth and fat reduction following focused electromagnetic stimulation.
High intensity focused electromagnetic therapy evaluated by magnetic resonance imaging: safety and efficacy study of a dual tissue effect based non-invasive abdominal body shaping
Kinney BM, Lozanova P. Lasers Surg Med. 2019;51(1):40–46. MRI study, n=22
MRI at two and six months showed simultaneous muscle growth, fat reduction, and reduced abdominal separation, unrelated to dieting.
Radiofrequency heating and high-intensity focused electromagnetic treatment delivered simultaneously: the first sham-controlled randomized trial
Samuels JB, Katz B, Weiss RA. Plast Reconstr Surg. 2022;149(5):893e–900e. Sham-controlled RCT
The first sham-controlled randomized trial of electromagnetic muscle stimulation, supporting efficacy versus placebo.
Radiofrequency heating and high-intensity focused electromagnetic treatment delivered simultaneously: the first sham-controlled randomized trial
Samuels JB, Katz B, Weiss RA. Plast Reconstr Surg. 2022;149(5):893e–900e. Sham-controlled RCT
The first sham-controlled randomized trial of the combined modality, supporting efficacy against placebo treatment.
Simultaneous changes in abdominal adipose and muscle tissues following treatments by high-intensity focused electromagnetic (HIFEM) technology-based device: computed tomography evaluation
Kent DE, Jacob CI. J Drugs Dermatol. 2019;18(11):1098–1102. CT study
CT imaging independently confirmed concurrent changes in abdominal muscle and adipose tissue after treatment.