Clinical evidence
The science, in the open.
Every claim traces to a study. Filter the library by device or indication — or start with the framework that connects them.
The MANA approach — our regeneration framework
A controlled trial to determine the efficacy of red and near-infrared light treatment in patient satisfaction, reduction of fine lines, wrinkles, skin roughness, and intradermal collagen density
Wunsch A, Matuschka K. Photomed Laser Surg. 2014;32(2):93–100. PMID 24286286. Controlled trial, n=136
Active treatment group demonstrated significant improvement in fine lines, skin roughness, and intradermal collagen density versus sham; patient satisfaction scores also significantly higher.
Advances in plasma skin regeneration
Foster KW, Moy RL, Fincher EF. J Cosmet Dermatol. 2008;7(3):169–179. doi:10.1111/j.1473-2165.2008.00389.x. PMID 18789051
Histological studies confirmed continued collagen production, reduction of elastosis, and progressive skin rejuvenation beyond one year after treatment; FDA 510(k) clearance for rhytides, skin lesions, and actinic keratoses.
Clinical application of radiofrequency technology in the treatment of facial skin wrinkles and laxity
Chen et al. J Cosmet Dermatol. 2024 (PMC 12243918). Prospective study, n=60
Three consecutive RF sessions produced statistically significant improvements in facial wrinkles and skin laxity in women aged 36–58.
Cold-shock proteins and the cryotherapy effects on human skin fibroblasts: possible applications in aesthetic medicine
Mancini F, et al. J Cosmet Dermatol. 2020;19(5):1128–1133. doi:10.1111/jocd.13152. PMID 31875638
Cold stimulation of skin fibroblasts produced measurable upregulation of cold-shock proteins and increased collagen synthesis markers, supporting a biological rationale for cryo-thermal skin priming in aesthetic applications.
Facial aesthetic treatments with plasma radiofrequency ablation
Baroni A, et al. J Cosmet Dermatol. 2021;20(8):2492–2496. PMID 33683794
Plasma radiofrequency ablation showed versatile efficacy across a range of facial aesthetic indications with rapid recovery time, described as "one of the most versatile minimally invasive techniques."
Fractional ablative carbon dioxide laser resurfacing for skin rejuvenation and acne scars in Asians
Chan NPY, Ho SGY, Yeung CK, Shek SYN, Chan HHL. Lasers Surg Med. 2010;42(9):615–623. PMID 20976801
Fractional CO2 laser was overall safe and effective for skin rejuvenation and acne scar treatment across Asian skin types, establishing a reference point for skin-of-color practice.
Mechanisms and applications of the anti-inflammatory effects of photobiomodulation
Hamblin MR. AIMS Biophys. 2017;4(3):337–361. PMID 28748217. Review
Comprehensive review establishing the cellular mechanisms by which photobiomodulation reduces inflammatory cytokines, supporting its application across acne, wound healing, and post-procedure recovery.
Microneedling: percutaneous collagen induction therapy for management of scars and photoaged skin — scientific evidence and review of the literature
Iriarte C, Awosika O, Rengifo-Pardo M, Ehrlich A. Aesthetic Plast Surg. 2020;44(6):2202–2214. PMID 32875437
Literature review of 25 published studies found consistent evidence for percutaneous collagen induction in scar remodeling and skin rejuvenation; method preserves epidermis while promoting regeneration.
Multicenter study of noninvasive radiofrequency for periorbital tissue tightening
Fitzpatrick R, Geronemus R, Goldberg D, Kaminer M, Kilmer S, Ruiz-Esparza J. Lasers Surg Med. 2003;33(4):232–242. Multicenter study, n=86
Blinded photographic scoring found wrinkle-score improvements in 83.2% of treated periorbital areas; 61.5% of eyebrows lifted by at least 0.5 mm at six months.
Percutaneous collagen induction therapy: an alternative treatment for scars, wrinkles, and skin laxity
Aust MC, Fernandes D, Kolokythas P, Kaplan HM, Vogt PM. Plast Reconstr Surg. 2008;121(4):1421–1429. PMID 18349650
Histological analysis confirmed collagen induction following microneedling, with clinical improvement in scars, wrinkles, and skin laxity; the technique was reproducible and well-tolerated.
Study 1
Placeholder Author et al. (2026). Study 1. Journal of Placeholder Medicine.
Placeholder summary for Study 1: design, cohort, endpoints, and outcomes at a glance.
The effect of combined red, blue, and near-infrared LED photobiomodulation on speed of wound healing after superficial ablative fractional resurfacing
Palm MD, et al. Lasers Surg Med. 2024;56(3):PMC10965566. Prospective intraindividual RCT, n=25
Three blinded evaluators found significantly faster wound closure on the LED-treated arm versus the untreated control arm following fractional resurfacing.
The role of heat shock proteins in collagen remodeling: implications for aesthetic energy devices
Metz C, Goffin L. J Cosmet Laser Ther. 2018;20(1):4–11. doi:10.1080/14764172.2017.1368634. PMID 28853624
Thermal stress (heat and cold) consistently upregulated HSP70 and HSP47 — the collagen-specific chaperone — in dermal fibroblasts, providing mechanistic support for temperature-conditioning protocols ahead of resurfacing procedures.
Treatment of acne scars with fractional CO2 laser at 1-month versus 3-month intervals: an intra-individual randomized controlled trial
Majid I, Imran S. J Cosmet Laser Ther. 2014;16(2):70–74. PMID 24018777. Intra-individual RCT
Fractional CO2 laser produced significant scar improvement regardless of treatment interval, confirming efficacy of the modality as a reliable standard.