Clinical evidence
The science, in the open.
Every claim traces to a study. Filter the library by device or indication — or start with the framework that connects them.
The MANA approach — our regeneration framework
Ablative fractional CO2 laser for facial atrophic acne scars: systematic review and evidence-based recommendations
Peng JH, et al. Dermatol Surg. 2018;44(2):187–200. PMID 29304516. Systematic review, 30 studies
Systematic review of 30 studies (12 retrospective, 18 RCTs) established ablative fractional CO2 as a well-validated treatment for acne scars with a comprehensive evidence base.
Fractional ablative carbon dioxide laser resurfacing for skin rejuvenation and acne scars in Asians
Chan NPY, Ho SGY, Yeung CK, Shek SYN, Chan HHL. Lasers Surg Med. 2010;42(9):615–623. PMID 20976801
Fractional CO2 laser was overall safe and effective for skin rejuvenation and acne scar treatment across Asian skin types, establishing a reference point for skin-of-color practice.
Mechanisms and applications of the anti-inflammatory effects of photobiomodulation
Hamblin MR. AIMS Biophys. 2017;4(3):337–361. PMID 28748217. Review
Comprehensive review establishing the cellular mechanisms by which photobiomodulation reduces inflammatory cytokines, supporting its application across acne, wound healing, and post-procedure recovery.
Microneedling therapy for atrophic acne scars: an objective evaluation
El-Domyati M, Barakat M, Awad S, Medhat W, El-Fakahany H, Farag H. J Clin Aesthet Dermatol. 2015;8(7):36–42. PMC4509584
Objective evaluation combining physician assessment and histological analysis confirmed significant atrophic scar improvement after microneedling; clinical and histological findings correlated.
Treatment of acne scars using the plasma skin regeneration system
Gonzalez MJ, et al. Lasers Surg Med. 2008;40(2):124–127. doi:10.1002/lsm.20617. PMID 18306162
Single high-energy treatment produced measurable acne-scar improvement at three and six months by physician and patient assessment.
Treatment of acne scars with fractional CO2 laser at 1-month versus 3-month intervals: an intra-individual randomized controlled trial
Majid I, Imran S. J Cosmet Laser Ther. 2014;16(2):70–74. PMID 24018777. Intra-individual RCT
Fractional CO2 laser produced significant scar improvement regardless of treatment interval, confirming efficacy of the modality as a reliable standard.